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Am J Obstet Gynecol. 2011 Sep;205(3):275.e1-5. doi: 10.1016/j.ajog.2011.06.043. Epub 2011 Jun 17.

Influence of gestational age and reason for prior preterm birth on rates of recurrent preterm delivery.

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1
Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL, USA.

Abstract

OBJECTIVE:

We sought to compare rates of recurrent spontaneous preterm birth (SPTB) in women receiving 17-α-hydroxyprogesterone caproate (17P) with prior SPTB due to preterm labor (PTL) vs preterm premature rupture of membranes (PPROM).

STUDY DESIGN:

Women with singleton gestation having 1 prior SPTB enrolled at 16-24.9 weeks' gestation for weekly outpatient 17P administration were identified from a database. Rates of recurrent SPTB were compared between those with prior SPTB due to PTL or PPROM overall and by gestational age at prior SPTB.

RESULTS:

Records from 2123 women were analyzed. The prior PTL group vs the prior PPROM group experienced higher rates of recurrent SPTB at <37 weeks (29.7% vs 22.9%, P = .004), <35 weeks (14.0% vs 9.1%, P = .004), and <32 weeks (5.9% vs 3.3%, P = .024), respectively.

CONCLUSION:

Reason and gestational age of prior SPTB influence the likelihood of recurrent SPTB in women receiving 17P prophylaxis.

PMID:
22071063
DOI:
10.1016/j.ajog.2011.06.043
[Indexed for MEDLINE]
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