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Curr Opin Microbiol. 2012 Feb;15(1):15-22. doi: 10.1016/j.mib.2011.10.009. Epub 2011 Nov 7.

Tissue microbiology provides a coherent picture of infection.

Author information

1
Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, S-17177 Stockholm, Sweden. agneta.richter.dahlfors@ki.se

Abstract

The vertebrate host represents an extraordinarily complex and heterogenous environment which pathogenic bacteria of different types able to colonize and infect. This implies that all contributory elements of an infected tissue type or intact host are pre-requisites for full understanding of bacterial pathogenesis. Within this context, intravital techniques allow such studies of infection under realistic conditions within the live host, and with improved detection methods another level of understanding is attained. Here we define this field as tissue microbiology, with its focus placed on monitoring and mimicking host-pathogen interaction within the dynamic micro-ecology significant for infectious niches in the live host. Such all-inclusive approaches promise to more coherently define relevant interactions and angles for disease intervention.

PMID:
22070968
DOI:
10.1016/j.mib.2011.10.009
[Indexed for MEDLINE]

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