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Tissue Eng Part C Methods. 2012 Apr;18(4):293-301. doi: 10.1089/ten.TEC.2011.0531. Epub 2011 Dec 22.

Metal mesh scaffold for tissue engineering of membranes.

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The Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department Biomedical Engineering, University of California, Irvine, CA 92697, USA.


Engineering of the membrane-like tissue structures to be utilized in highly dynamic loading environments such as the cardiovascular system has been a challenge in the past decade. Scaffolds are critical components of the engineered tissue membranes and allow them being formed in vitro and remain secure in vivo when implanted in the body. Several approaches have been taken to develop scaffolds for tissue membranes. However, all methods entail limitations due to structural vulnerability, short-term functionality, and mechanical properties of the resulted membrane constructs. To overcome these issues, we have developed a novel hybrid scaffold made of an extra thin layer of metal mesh tightly enclosed by biological matrix components. This approach retains all the advantages of using biological scaffolds while developing a strong extracellular matrix that can stand various types of loads after implantation inside the body.

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