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Am J Reprod Immunol. 2012 Mar;67(3):241-50. doi: 10.1111/j.1600-0897.2011.01090.x. Epub 2011 Nov 10.

Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.

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1
Department of Obstetrics, Sao Paulo Federal University, Sao Paulo, Brazil.

Abstract

PROBLEM:

Our study aimed to assess in vitro production of IL-10, IL-6, TNF-A, and adiponectin serum levels in pregnant women with and without gestational diabetes mellitus (GDM) and to investigate a possible association between GDM and IL-10-1082 A>G (rs1800896), IL-6-174 G>C (rs1800795), TNF-A-308 G>A (rs1800629), adiponectin +45 T>G (rs2241766), and adiponectin-11377 C>G (rs266729) gene polymorphisms.

METHOD OF STUDY:

This case-control study included 79 women with GDM and 169 healthy controls (C) grouped according to pre-pregnancy BMI. IL-10, IL-6, and TNF-A culture supernatant and adiponectin serum levels were assessed by ELISA. DNA genotype was performed by PCR-RFLP.

RESULTS:

Adiponectin levels were significantly higher in C than GDM women, even within the same BMI category. Cytokines levels were similar between the groups. There were no associations between GDM and the analyzed gene polymorphisms.

CONCLUSIONS:

Women with GDM have significantly lower adiponectin levels in the third trimester, regardless of BMI.

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