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Toxins (Basel). 2011 Sep;3(9):1131-45. doi: 10.3390/toxins3091131. Epub 2011 Sep 9.

Role of the mannose receptor (CD206) in innate immunity to ricin toxin.

Author information

  • 1Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA. gage.emily@gmail.com

Abstract

The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure. It has been proposed that uptake of ricin into macrophages is facilitated by the mannose receptor (MR; CD206), a C-type lectin known to recognize the oligosaccharide side chains on ricin's A (RTA) and B (RTB) subunits. In this study, we confirmed that the MR does indeed promote ricin binding, uptake and killing of monocytes in vitro. To assess the role of MR in the pathogenesis of ricin in vivo, MR knockout (MR(-/-)) mice were challenged with the equivalent of 2.5× or 5× LD(50) of ricin by intraperitoneal injection. We found that MR(-/-) mice were significantly more susceptible to toxin-induced death than their age-matched, wild-type control counterparts. These data are consistent with a role for the MR in scavenging and degradation of ricin, not facilitating its uptake and toxicity in vivo.

KEYWORDS:

C-type lectins; biodefense; pathogenesis; toxin

PMID:
22069759
PMCID:
PMC3202876
DOI:
10.3390/toxins3091131
[PubMed - indexed for MEDLINE]
Free PMC Article
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