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Toxins (Basel). 2010 Nov;2(11):2490-518. doi: 10.3390/toxins2112490. Epub 2010 Oct 26.

Mechanisms of Cisplatin nephrotoxicity.

Author information

1
Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA, USA. RMiller8@hmc.psu.edu

Abstract

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.

KEYWORDS:

apoptosis; cisplatin; cytokines; dendritic cells; inflammation; kidney injury; nephrotoxicity; toll-like receptors

PMID:
22069563
PMCID:
PMC3153174
DOI:
10.3390/toxins2112490
[Indexed for MEDLINE]
Free PMC Article

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