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J Biol Chem. 2012 Jan 2;287(1):29-34. doi: 10.1074/jbc.R111.240945. Epub 2011 Nov 8.

Divergent evolution in enolase superfamily: strategies for assigning functions.

Author information

1
Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA. j-gerlt@uiuc.edu

Abstract

Nature's strategies for evolving catalytic functions can be deciphered from the information contained in the rapidly expanding protein sequence databases. However, the functions of many proteins in the protein sequence and structure databases are either uncertain (too divergent to assign function based on homology) or unknown (no homologs), thereby limiting the utility of the databases. The mechanistically diverse enolase superfamily is a paradigm for understanding the structural bases for evolution of enzymatic function. We describe strategies for assigning functions to members of the enolase superfamily that should be applicable to other superfamilies.

PMID:
22069326
PMCID:
PMC3249080
DOI:
10.1074/jbc.R111.240945
[Indexed for MEDLINE]
Free PMC Article
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