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Org Lett. 2011 Dec 2;13(23):6180-3. doi: 10.1021/ol202565j. Epub 2011 Nov 9.

Synthesis of substituted isoquinolines via Pd-catalyzed cross-coupling approaches.

Author information

1
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4M1.

Abstract

Palladium complexes incorporating ligands based on a 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantanyl scaffold were used to catalyze the arylation of ethyl cyanoacetate, malononitrile, and various ketones. The products from these reactions can be elaborated to substituted β-arylethylamines and used in microwave-assisted Pictet-Spengler reactions. The protocol developed is suitable for the synthesis of libraries of substituted isoquinolines.

PMID:
22066469
DOI:
10.1021/ol202565j

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