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Nucleic Acids Res. 2012 Jan;40(Database issue):D1036-40. doi: 10.1093/nar/gkr899. Epub 2011 Nov 3.

DistiLD Database: diseases and traits in linkage disequilibrium blocks.

Author information

1
Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Abstract

Genome-wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of hundreds of diseases. However, there is currently no database that enables non-specialists to answer the following simple questions: which SNPs associated with diseases are in linkage disequilibrium (LD) with a gene of interest? Which chromosomal regions have been associated with a given disease, and which are the potentially causal genes in each region? To answer these questions, we use data from the HapMap Project to partition each chromosome into so-called LD blocks, so that SNPs in LD with each other are preferentially in the same block, whereas SNPs not in LD are in different blocks. By projecting SNPs and genes onto LD blocks, the DistiLD database aims to increase usage of existing GWAS results by making it easy to query and visualize disease-associated SNPs and genes in their chromosomal context. The database is available at http://distild.jensenlab.org/.

PMID:
22058129
PMCID:
PMC3245128
DOI:
10.1093/nar/gkr899
[Indexed for MEDLINE]
Free PMC Article

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