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Nat Neurosci. 2011 Nov 6;14(12):1510-2. doi: 10.1038/nn.2971.

Cholinergic modulation of a specific memory function of prefrontal cortex.

Author information

1
Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute, Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.

Abstract

Deficits in prefrontal cholinergic function are implicated in cognitive impairment in many neuropsychiatric diseases, but acetylcholine's specific role remains elusive. Rhesus monkeys with selective lesions of cholinergic input to prefrontal cortex (PFC) were unimpaired in tests of decision making and episodic memory that require intact PFC, but were severely impaired on a spatial working memory task. These observations are consistent with a specific role for prefrontal acetylcholine in working memory.

PMID:
22057191
PMCID:
PMC3432567
DOI:
10.1038/nn.2971
[Indexed for MEDLINE]
Free PMC Article

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