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Mol Cell Endocrinol. 2012 Mar 31;351(1):111-7. doi: 10.1016/j.mce.2011.09.044. Epub 2011 Oct 25.

Gene expression profiling in adrenocortical neoplasia.

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  • 1INSERM U1016, Institut Cochin, Paris, France. guillaume.assie@cch.aphp.fr

Abstract

Transcriptome studies of adrenocortical tumors have shown clear differences between adenomas and carcinomas and identified two subgroups of carcinomas with different prognoses. This review focuses on how transcriptomes have enriched our knowledge about genes previously identified by classical candidate gene approaches, uncovered novel genes relevant to adrenocortical tumor biology, helped to identify and understand specific pathway alterations, and advanced the overall translational relevance of this field of research.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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