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Cell Metab. 2011 Nov 2;14(5):571-2. doi: 10.1016/j.cmet.2011.10.005.

A PGC-1 tale: healthier intestinal stem cells, longer life.

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1
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

Abstract

PGC-1 regulates energy homeostasis and mitochondrial activity. In this issue, Rera et al. (2011) show that dPGC-1 overexpression in Drosophila intestinal stem cells and their immediate progeny extends organismal life span and protects against age-related loss of intestinal homeostasis and integrity, thereby establishing a link between mitochondria, tissue stem cells, and aging.

PMID:
22055499
DOI:
10.1016/j.cmet.2011.10.005
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