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Mol Cell. 2011 Nov 4;44(3):348-60. doi: 10.1016/j.molcel.2011.09.014.

Regulation of primary response genes.

Author information

1
Department of Pathology, Sackler School of Biomedical Science, Tufts University School of Medicine, Boston, MA 02111, USA.

Abstract

Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. These "first responders" in the waves of transcription of signal-responsive genes play pivotal roles in a wide range of biological responses, including neuronal survival and plasticity, cardiac stress response, innate and adaptive immune responses, glucose metabolism, and oncogeneic transformation. Here we bring together recent advances and our current understanding of the signal-induced transcriptional and epigenetic regulation of PRGs.

PMID:
22055182
PMCID:
PMC3212756
DOI:
10.1016/j.molcel.2011.09.014
[Indexed for MEDLINE]
Free PMC Article

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