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Curr Opin Genet Dev. 2011 Dec;21(6):787-98. doi: 10.1016/j.gde.2011.10.003. Epub 2011 Nov 4.

Networks in Caenorhabditis elegans.

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Center for Genomics and Systems Biology and Department of Biology, New York University, 12 Waverly Place, 8th floor, New York, NY 10012, USA.


The network paradigm has become a pervasive theme in biology over the last decade, as increasingly large functional genomic datasets are being collected to interrogate regulatory influences, physical interactions, and genetic dependencies between genes, transcripts, and proteins. These 'molecular interaction' networks can be analyzed collectively and individually to define their global architecture and local patterns of connectivity. These structural features ultimately underlie functional properties such as robustness, modularity, component circuitry (e.g. feedback loops), dynamics, and responses to perturbations. This review focuses on recent progress in elucidating molecular interaction networks using different kinds of functional assays in the classical genetic model for animal development, the roundworm Caenorhabditis elegans, with representative examples to illustrate current directions in different areas of network biology.

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