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Annu Rev Pathol. 2012;7:385-422. doi: 10.1146/annurev-pathol-011811-132448. Epub 2011 Nov 4.


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St. John's Institute of Dermatology, King's College London, London SE1 9RT, United Kingdom.


Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies.

[Indexed for MEDLINE]

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