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Science. 2011 Nov 4;334(6056):623-8. doi: 10.1126/science.1209236.

The cell biology of synaptic plasticity.

Author information

1
Interdepartmental Program in Neurosciences, University of California-Los Angeles (UCLA), BSRB 390B, 615 Charles E. Young Drive South, Los Angeles, CA 90095-1737, USA.

Abstract

Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.

PMID:
22053042
PMCID:
PMC3286636
DOI:
10.1126/science.1209236
[Indexed for MEDLINE]
Free PMC Article
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