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Prion. 2011 Oct-Dec;5(4):245-9. doi: 10.4161/pri.17749. Epub 2011 Oct 1.

Modulation and elimination of yeast prions by protein chaperones and co-chaperones.

Author information

1
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

The yeast system has provided considerable insight into the biology of amyloid and prions. Here we focus on how alterations in abundance or function of protein chaperones and co-chaperones affect propagation of yeast prions. In spite of a considerable amount of information, a clear understanding of the molecular mechanisms underlying these effects remains wanting.

PMID:
22052352
PMCID:
PMC4012410
DOI:
10.4161/pri.17749
[Indexed for MEDLINE]
Free PMC Article
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