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Cell Death Differ. 2012 Jan;19(1):28-35. doi: 10.1038/cdd.2011.153. Epub 2011 Nov 4.

A quarter century of granzymes.

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1
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.

Abstract

Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs.

PMID:
22052191
PMCID:
PMC3252830
DOI:
10.1038/cdd.2011.153
[Indexed for MEDLINE]
Free PMC Article
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