Abstract
Granzymes (Grs) were discovered just over a quarter century ago. They are produced by cytotoxic T cells and natural killer cells and are released upon interaction with target cells. Intensive biochemical, genetic, and biological studies have been performed in order to study their roles in immunity and inflammation. This review summarizes research on the family of Grs.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis*
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Caspase 3 / genetics
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Caspase 3 / metabolism
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Granzymes / genetics
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Granzymes / history
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Granzymes / physiology*
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History, 20th Century
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History, 21st Century
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Humans
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Immunity / genetics
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Inflammation / genetics
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Inflammation / immunology*
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Killer Cells, Natural / cytology
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Killer Cells, Natural / immunology*
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Mice
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Perforin / genetics
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Perforin / immunology
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T-Lymphocytes, Cytotoxic / cytology
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Perforin
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Granzymes
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Caspase 3