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Dalton Trans. 2011 Dec 21;40(47):12660-2. doi: 10.1039/c1dt11545f. Epub 2011 Nov 3.

Design of a magnesium-pridinolum complex for polylactide-drug conjugates formation.

Author information

1
Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383, Wroclaw, Poland.

Abstract

Polylactide conjugates of the muscle contraction agent Pridinolum (PriOH = 1,1-diphenyl-3-(1-piperidinyl)-1-propanol) were prepared directly by ring-opening polymerization of L-lactide (L-LA) mediated by the pridinolum magnesium complex [Mg(μ,η(2)-OPri)(η(1)-OPri)](2). The ancillary O,N - bifunctional drug as a ligand stabilizes the magnesium species and initiates L-LA polymerization affording a polymer chain terminated by covalently attached drug molecules to the PLLA through ester linkers to form PriO-PLLA conjugate. Up to 80% of the pridinolum can be released from the conjugate by treatment with deuterated hydrochloric acid DCl at pH = 1.5 for 10 h at 37 °C.

PMID:
22051772
DOI:
10.1039/c1dt11545f
[Indexed for MEDLINE]

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