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Yale J Biol Med. 1990 Mar-Apr;63(2):173-82.

Modulation of host defense by the neuropeptide alpha-MSH.

Author information

1
Department of Physiology, University of Texas Southwestern Medical Center, Dallas.

Abstract

alpha-melanocyte stimulating hormone (alpha-MSH), a peptide that occurs within the brain, the circulation, and other body sites, is a potent antipyretic agent when given centrally or peripherally. The peptide likewise inhibits inflammation and aspects of the acute-phase response. The combined evidence suggests that alpha-MSH molecules act as natural modulators of host reactions by antagonizing the central and peripheral actions of cytokines.

PMID:
2205057
PMCID:
PMC2589306
[Indexed for MEDLINE]
Free PMC Article

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