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Epilepsy Res. 2012 Mar;99(1-2):167-70. doi: 10.1016/j.eplepsyres.2011.10.011. Epub 2011 Nov 1.

Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.

Author information

1
Department of Physiology, University of Kentucky, Lexington, KY 40536-0298, USA.

Abstract

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

PMID:
22047981
PMCID:
PMC3290720
DOI:
10.1016/j.eplepsyres.2011.10.011
[Indexed for MEDLINE]
Free PMC Article

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