Lancet Oncol. 2012 Jan;13(1):e11-22. doi: 10.1016/S1470-2045(11)70175-9. Epub 2011 Oct 31.

Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report.

Clavien PA¹, Lesurtel M, Bossuyt PM, Gores GJ, Langer B, Perrier A; OLT for HCC Consensus Group.

Collaborators (110)

Abecassis M, Balabaud C, Barritt GJ, Belghiti J, Bhoori S, Bossuyt P, Breitenstein S, Broelsch C, Bruix J, Burra P, Burroughs A, Busuttil R, Charlton M, Cherqui D, Clavien PA, Colombo ML, d'Albuquerque C, D'Alessandro A, de Santibañez EJ, Dufour F, Durand F, Dutkowski P, Duvoux C, El-Serag H, Fan ST, Finn RS, Fisher R, Forner A, Freeman R, Fung J, Geier A, Germani G, Gores G, Gouw AS, Grant D, Greig P, Gurusamy K, Hanto D, Heaton N, Heim M, Hemming A, Hippen B, Hisham A, Hubscher S, Ichida T, Kahn D, Kew M, Kita Y, Kiuchi T, Klintmalm GB, Kneteman N, Kojiro M, Kudo M, Langer B, Lee JM, Lee SG, Lencioni R, Lerut J, Lesurtel M, Livraghi T, Llovet J, Lo CM, Lodge P, MacCaughan G, Madoff D, Majno P, Marcellin P, Marrero J, Mazzaferro V, Mergental H, Merle P, Miksad R, Mornex F, Müllhaupt B, Olthoff K, Paradis V, Perrier A, Pestalozzi B, Pomfret E, Poon R, Porte R, Greig P, Prasad KR, Raptis D, Roskams T, Rossi M, Samuel D, Schlitt H, Schwartz M, Sexton Dobby AM, Shaked A, Sherman M, Siegler M, Suh KS, Todo S, Toso C, Trevisani F, Trotter JJ, Valdecasas GJ, Vauthey N, Vilgrain V, Villamil F, Vonlanthen R, Wald C, Weber A, Wiesner R, Wright L, Yao F, Zheng SS, Zucman-Rossi J.

Author information

1: Department of Surgery, Swiss HPB and Transplant Centers, University Hospital Zurich, Zurich, Switzerland. clavien@access.uzh.ch

Abstract

Although liver transplantation is a widely accepted treatment for hepatocellular carcinoma (HCC), much controversy remains and there is no generally accepted set of guidelines. An international consensus conference was held on Dec 2-4, 2010, in Zurich, Switzerland, with the aim of reviewing current practice regarding liver transplantation in patients with HCC and to develop internationally accepted statements and guidelines. The format of the conference was based on the Danish model. 19 working groups of experts prepared evidence-based reviews according to the Oxford classification, and drafted recommendations answering 19 specific questions. An independent jury of nine members was appointed to review these submissions and make final recommendations, after debates with the experts and audience at the conference. This report presents the final 37 statements and recommendations, covering assessment of candidates for liver transplantation, criteria for listing in cirrhotic and non-cirrhotic patients, role of tumour downstaging, management of patients on the waiting list, role of living donation, and post-transplant management.