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Fertil Steril. 2011 Dec;96(6):1370-1374.e1. doi: 10.1016/j.fertnstert.2011.09.044. Epub 2011 Nov 1.

Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study.

Author information

1
The Egyptian IVF-ET Center, Cairo, Egypt. ragaa.mansour@gmail.com

Abstract

OBJECTIVE:

To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).

DESIGN:

Prospective randomized study.

SETTING:

The Egyptian IVF-ET Center.

PATIENT(S):

Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).

INTERVENTION(S):

The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy rate (PR) and implantation rate (IR).

RESULT(S):

The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference.

CONCLUSION(S):

Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI. CLINICAL TRIALS.GOV NUMBER: NCT 01030393.

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[Indexed for MEDLINE]

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