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ACS Chem Biol. 2012 Feb 17;7(2):269-77. doi: 10.1021/cb2003626. Epub 2011 Nov 15.

Targeting the assembly of bacterial cell division protein FtsZ with small molecules.

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1
Tubulins and FtsZ, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.

Abstract

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of FtsZ-interacting compounds have been reported, some of which have powerful antibacterial activity. Here we review recent advances and new approaches in modulating FtsZ assembly with small molecules. This includes analyzing their chemical features, binding sites, mechanisms of action, the methods employed, and computational insights, aimed at a better understanding of their molecular recognition by FtsZ and at rational antibiotic design.

PMID:
22047077
DOI:
10.1021/cb2003626
[Indexed for MEDLINE]
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