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PLoS One. 2011;6(10):e26503. doi: 10.1371/journal.pone.0026503. Epub 2011 Oct 26.

Sensory coding by cerebellar mossy fibres through inhibition-driven phase resetting and synchronisation.

Author information

1
Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom. th247@cam.ac.uk

Abstract

Temporal coding of spike-times using oscillatory mechanisms allied to spike-time dependent plasticity could represent a powerful mechanism for neuronal communication. However, it is unclear how temporal coding is constructed at the single neuronal level. Here we investigate a novel class of highly regular, metronome-like neurones in the rat brainstem which form a major source of cerebellar afferents. Stimulation of sensory inputs evoked brief periods of inhibition that interrupted the regular firing of these cells leading to phase-shifted spike-time advancements and delays. Alongside phase-shifting, metronome cells also behaved as band-pass filters during rhythmic sensory stimulation, with maximal spike-stimulus synchronisation at frequencies close to the idiosyncratic firing frequency of each neurone. Phase-shifting and band-pass filtering serve to temporally align ensembles of metronome cells, leading to sustained volleys of near-coincident spike-times, thereby transmitting synchronised sensory information to downstream targets in the cerebellar cortex.

PMID:
22046297
PMCID:
PMC3202539
DOI:
10.1371/journal.pone.0026503
[Indexed for MEDLINE]
Free PMC Article
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