Format

Send to

Choose Destination
J Clin Invest. 2011 Nov;121(11):4222-30. doi: 10.1172/JCI57144. Epub 2011 Nov 1.

Ceramides as modulators of cellular and whole-body metabolism.

Author information

1
Duke–National University of Singapore Graduate Medical School, Singapore.

Abstract

Nearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites. While the role of these lipids in the regulation of cell growth and death has been studied extensively, recent studies suggest that a primary consequence of ceramide accumulation is an alteration in metabolism. In both cell-autonomous systems and complex organisms, ceramides modify intracellular signaling pathways to slow anabolism, ensuring that catabolism ensues. These ceramide actions have important implications for diseases associated with obesity, such as diabetes and cardiovascular disease.

PMID:
22045572
PMCID:
PMC3204836
DOI:
10.1172/JCI57144
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center