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Semin Cell Dev Biol. 2012 Feb;23(1):7-15. doi: 10.1016/j.semcdb.2011.10.026. Epub 2011 Oct 24.

Eph and ephrin signaling in the formation of topographic maps.

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1
Molecular, Cell & Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.

Abstract

The axonal connections between the retina and its midbrain target, the superior colliculus (SC), is mapped topographically, such that the spatial relationships of cell bodies in the retina are maintained when terminating in the SC. Topographic map development uses a Cartesian mapping system such that each axis of the retina is mapped independently. Along the nasal-temporal mapping axis, EphAs and ephrin-As, are graded molecular cues required for topographic mapping while the dorsal-ventral axis is mapped in part via EphB and ephrin-Bs. Because both Ephs and ephrins are cell surface molecules they can signal in the forward and reverse directions. Eph/ephrin signaling leads to changes in cytoskeletal dynamics that lead to actin depolymerization and endocytosis guiding axons via attraction and repulsion.

PMID:
22044886
PMCID:
PMC3288406
DOI:
10.1016/j.semcdb.2011.10.026
[Indexed for MEDLINE]
Free PMC Article
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