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Diabetes Technol Ther. 2012 Mar;14(3):257-63. doi: 10.1089/dia.2011.0172. Epub 2011 Nov 1.

Oxidative stress in preretinopathic diabetes subjects and antioxidants.

Author information

1
Department of Sense Organs, Sapienza University of Rome, Rome, Italy. marcella.nebbioso@uniroma1.it

Abstract

BACKGROUND:

This study assessed the effect of a systemic oral treatment with antioxidants (AOs) in preretinopathic diabetes (PRD) patients, through the evaluation of oxidative stress in plasma and changes in the full-field electroretinogram (ERG).

METHODS:

Thirty-two PRD subjects with good metabolic control were recruited. Patients were randomized in two groups, one of which received oral AO treatment with α-lipoic acid at 400 mg/day in association with genistein and vitamins, whereas the other group received a placebo. Free radicals and the AO barrier were evaluated in plasma with the Free Radical Analytical System 4 instrument (H&D srl, Parma, Italy), and the same day the electrophysiological response was measured by ERG. These analyses were performed at enrollment and after 30 days of treatment.

RESULTS:

Statistically significant increases of plasma AO levels and ERG oscillatory potential values were observed in the group treated with AO, but not in the control group.

CONCLUSIONS:

Results of this preliminary study suggest that an oral treatment with AOs in PRD subjects may have a protective effect on retinal cells, as detected by ERG analysis, through the strengthening of the plasma AO barrier.

PMID:
22044044
DOI:
10.1089/dia.2011.0172
[Indexed for MEDLINE]

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