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Immunology. 2012 Jan;135(1):9-18. doi: 10.1111/j.1365-2567.2011.03515.x.

Structural and biophysical determinants of αβ T-cell antigen recognition.

Author information

1
Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, UK.

Abstract

The molecular rules that govern MHC restriction, and allow T-cells to differentiate between peptides derived from healthy cells and those from diseased cells, remain poorly understood. Here we provide an overview of the structural constraints that enable the T-cell receptor (TCR) to discriminate between self and non-self peptides, and summarize studies that have attempted to correlate the biophysical parameters of TCR/peptide-major histocompatibility complex (pMHC) binding with T-cell activation. We further review how the antigenic origin of peptide epitopes affects TCR binding parameters and the 'quality' of a T-cell response. Understanding the principles that govern pMHC recognition by T-cells will unlock pathways to the rational development of immunotherapeutic approaches for the treatment of infectious disease, cancer and autoimmunity.

PMID:
22044041
PMCID:
PMC3246648
DOI:
10.1111/j.1365-2567.2011.03515.x
[Indexed for MEDLINE]
Free PMC Article

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