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Expert Rev Vaccines. 2011 Nov;10(11):1569-83. doi: 10.1586/erv.11.135.

Developments in virus-like particle-based vaccines for infectious diseases and cancer.

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1
Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori Fond Pascale, Via Mariano Semmola 142, 80131 Napoli, Italy. irccsvir@unina.it

Abstract

Virus-like particles hold great promise for the development of effective and affordable vaccines. Indeed, virus-like particles are suitable for presentation and efficient delivery of linear as well as conformational antigens to antigen-presenting cells. This will ultimately result in optimal B-cell activation and cross-presentation with both MHC class I and II molecules to prime CD4(+) T-helper as well as CD8(+) cytotoxic T cells. This article provides an update on the development and use of virus-like particles as vaccine approaches for infectious diseases and cancer.

PMID:
22043956
DOI:
10.1586/erv.11.135
[Indexed for MEDLINE]
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