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Can Vet J. 2011 May;52(5):501-5.

Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch.

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1
Department of Clinical Sciences (Companion Animals), Faculty of Veterinary Medicine, University of Liège, boulevard de Colonster, 20, B44, 4000 Liège, Belgium. Stephanie.Claeys@ulg.ac.be

Abstract

The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).

PMID:
22043069
PMCID:
PMC3078002
[Indexed for MEDLINE]
Free PMC Article
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