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Trends Biochem Sci. 1990 Aug;15(8):309-14.

Beta-galactoside transport in E. coli: a functional dissection of lac permease.

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Howard Hughes Medical Institute, Molecular Biology Institute, Los Angeles, CA 90024-1570.


The polytopic membrane protein lac permease harnesses energy from the electrochemical H+ gradient to transport beta-galactosidases against a concentration gradient. Although high-resolution structural information is still lacking, the permease is thought to possess 12 membrane-spanning alpha-helical segments. Various experimental strategies, including site-directed mutagenesis, have been employed to probe the function of this membrane protein at the molecular level.

[Indexed for MEDLINE]

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