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Trends Biochem Sci. 1990 Aug;15(8):291-4.

Why are proteins O-glycosylated?

Author information

1
Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.

Abstract

The O-linked oligosaccharides of glycoproteins are usually clustered within heavily glycosylated regions of the peptide chain. Steric interactions between carbohydrate and peptide within these clusters induce the peptide core to adopt a stiff and extended conformation and this conformational effect appears to represent a major function of O-glycosylation.

PMID:
2204153
[Indexed for MEDLINE]

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