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World J Gastroenterol. 2011 Sep 28;17(36):4113-7. doi: 10.3748/wjg.v17.i36.4113.

Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis.

Author information

1
Department of Digestive Tract Diseases, Medical University, 22 Kopcinskiego, 90-153 Lodz, Poland. renata.talar-wojnarowska@umed.lodz.pl

Abstract

AIM:

To evaluate the clinical significance of -765G/C and -1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).

METHODS:

The study included 201 patients: 85 with PC and 116 healthy controls. -765G/C and -1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood samples. The associations of the analyzed genotypes and clinical data at diagnosis were evaluated.

RESULTS:

We found an increased frequency of the homozygous -1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P < 0.01). In contrast, the distribution of genotype and allele frequencies of the -765G/C COX-2 polymorphism in the PC patients were not different from those in control groups. A correlation between presence of homozygous -1195AA COX-2 genotype and tumor size > 3 cm was observed (P < 0.05). Analyzed polymorphisms were unrelated to the patients' sex and age, nor to the presence of regional or distant metastases.

CONCLUSION:

These preliminary results indicate that the -1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis.

KEYWORDS:

Carcinogenesis; Cyclooxygenase-2; Pancreatic cancer; Polymorphisms

PMID:
22039326
PMCID:
PMC3203363
DOI:
10.3748/wjg.v17.i36.4113
[Indexed for MEDLINE]
Free PMC Article

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