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Mol Nutr Food Res. 2011 Dec;55(12):1905-8. doi: 10.1002/mnfr.201100216. Epub 2011 Oct 31.

Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo.

Author information

1
Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Abstract

Immune modulation has been a sought after means of therapy for atopic diseases. CVT-E002 is an extract derived from North American Ginseng shown to promote T-helper-1-like responses. We determined what effect CVT-E002 could have in a mouse model of atopic asthma. We report that oral CVT-E002 inhibited the development of allergic airway inflammation and airway hyperresponsiveness. This correlated with an increased presence of interferon-γ in the lung, and also increased regulatory T cells and IL-10. The ability of CVT-E002 to induce regulatory T-cell development was also seen in human in vitro co-cultures.

PMID:
22038929
DOI:
10.1002/mnfr.201100216
[Indexed for MEDLINE]

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