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Ir J Med Sci. 2012 Mar;181(1):53-8. doi: 10.1007/s11845-011-0775-4. Epub 2011 Oct 29.

Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection.

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1
Liver Unit, St Vincent's University Hospital, Dublin 4, Ireland. shehzad32@hotmail.com

Abstract

BACKGROUND:

The response to the treatment with pegylated interferon (PEG IFN)-α combined with ribavirin in chronic hepatitis C virus (HCV) infection varies with some patients having a rapid or early response which is not sustained.

AIMS:

To investigate the rates of rapid virological response (RVR), early virological response (EVR) and sustained virological response (SVR) in an Irish cohort of HCV infected patients receiving IFN-α/ribavirin.

METHODS:

Rates of RVR, EVR and SVR were examined in 123 patients undergoing standard treatment for chronic HCV infection between 2001 and 2007 at a Dublin Teaching Hospital.

RESULTS:

The rates of RVR, EVR and SVR in genotype 1 patients were 48, 68 and 50%, while in genotype 2/3 patients they were 87, 93 and 87%, respectively. The positive predictive values (PPV) of RVR for SVR in genotype 1 and genotype 2/3 patients were 90 and 92.4%, respectively.

CONCLUSION:

The rates of response to PEG IFN-α/ribavirin in Irish patients are consistent with other international reports. We support the regular monitoring of rapid and early virological response as a standard of care in treating chronic hepatitis C patients.

PMID:
22038749
DOI:
10.1007/s11845-011-0775-4
[Indexed for MEDLINE]
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