Synthesis and characterization of a template-assembled synthetic U-quartet

Chem Commun (Camb). 2012 Jan 4;48(1):109-11. doi: 10.1039/c1cc15608j. Epub 2011 Oct 31.

Abstract

A lipophilic cavitand containing four triazole-linked uridine residues has been synthesized and characterized. Spectral evidence suggests a quartet arrangement of the uracil residues at both ambient and low temperatures. Treatment of the compound with Sr(2+) yields a homodimeric complex as evidenced by NMR spectroscopy.

MeSH terms

  • Chemistry Techniques, Synthetic / methods*
  • Ethers, Cyclic / chemistry
  • Hydrophobic and Hydrophilic Interactions
  • Magnetic Resonance Spectroscopy
  • Nucleic Acid Conformation
  • Resorcinols / chemistry
  • Uridine / chemistry*

Substances

  • Ethers, Cyclic
  • Resorcinols
  • cavitand
  • Uridine