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Arch Gynecol Obstet. 2012 Apr;285(4):1145-51. doi: 10.1007/s00404-011-2120-6. Epub 2011 Oct 30.

Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20.

Author information

1
Department of Biochemistry, Faculty of Natural Sciences, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Strasse 3, 18059 Rostock, Germany. sibylle.abarzua@uni-rostock.de

Abstract

PURPOSE:

Phytoestrogens are plant-derived, non-steroidal phytochemicals with anticarcinogenic potential. The major structural classes are the isoflavones and lignans. The aim of this study was to compare the effect of the plant-derived lignans secoisolariciresinol and matairesinol with the human lignans enterodiol and enterolactone as well as with 17β estradiol and tamoxifen on cell proliferation of breast carcinoma cell lines.

METHODS:

The influence of the lignans, 17β estradiol and tamoxifen on cell proliferation was determined using the BrdU test in MCF 7 and BT 20 cell lines.

RESULTS:

Enterodiol and enterolactone induced a stronger inhibition of cell growth in MCF 7 and BT 20 cells than secoisolariciresinol and matairesinol. The inhibition effects were less expressed in the BT 20 than in the MCF 7 cells.

CONCLUSIONS:

The human lignans enterodiol and enterolactone are more biologically active than their precursors secoisolariciresinol and matairesinol, and may be defined as the real drugs in cancer prevention.

PMID:
22037685
DOI:
10.1007/s00404-011-2120-6
[Indexed for MEDLINE]

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