Bioorg Med Chem Lett. 2011 Dec 15;21(24):7434-9. doi: 10.1016/j.bmcl.2011.10.004. Epub 2011 Oct 12.

Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum.

Cheng YX¹, Zhou LL, Yan YM, Chen KX, Hou FF.

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1: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. yxcheng@mail.kib.ac.cn

Abstract

Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 μM.

PMID:: 22036992
DOI:: 10.1016/j.bmcl.2011.10.004

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Diabetic nephropathy-related active cyclic peptides from the roots of Brachystemma calycinum.

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