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Adv Drug Deliv Rev. 2012 May 15;64(7):598-604. doi: 10.1016/j.addr.2011.10.005. Epub 2011 Oct 20.

Guided delivery of adeno-associated viral vectors into the primate brain.

Author information

1
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103–0555, USA.

Abstract

In this review, we discuss recent developments in the delivery of adeno-associated virus-based vectors (AAV), particularly with respect to the role of axonal transport in vector distribution in the brain. The use of MRI-guidance and new stereotactic aiming devices have now established a strong foundation for neurological gene therapy to become an accepted procedure in interventional neurology.

PMID:
22036906
PMCID:
PMC3279613
DOI:
10.1016/j.addr.2011.10.005
[Indexed for MEDLINE]
Free PMC Article

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