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Cell. 2011 Oct 28;147(3):491-3. doi: 10.1016/j.cell.2011.10.007.

Dueling Ca2+ sensors in neurotransmitter release.

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Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.


Ca(2+)-triggered neurotransmitter release is characterized by two kinetically distinct components: a fast synchronous phase and a slow asynchronous phase. Yao et al. (2011) now report that double C2 domain (Doc2) proteins function as high-affinity Ca(2+) sensors to specifically regulate the asynchronous component of neurotransmitter release.

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