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Chem Biol. 2011 Oct 28;18(10):1204-5. doi: 10.1016/j.chembiol.2011.10.004.

Biology-driven library design for probe discovery.

Author information

1
NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. jinglese@mail.nih.gov

Abstract

Libraries of diverse small molecules are important to probe and drug discovery. The current trend toward building massive screening collections to support drug development, a special application of chemical biology, can limit their broader potential. Biology-driven construction methods (Wallace et al., 2011) are rapidly emerging to bring chemical libraries back on a viable path.

PMID:
22035786
DOI:
10.1016/j.chembiol.2011.10.004
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