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Am J Ophthalmol. 2012 Mar;153(3):460-467.e1. doi: 10.1016/j.ajo.2011.08.033. Epub 2011 Oct 29.

Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.

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1
Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232-8808, USA.

Abstract

PURPOSE:

To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes.

DESIGN:

Prospective case-control study.

METHODS:

Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes.

RESULTS:

CySS was elevated in cases compared with controls (P = .013). After adjustment for age, sex, and smoking, this association was not significant. In all participants, CySS levels were associated with the CFH polymorphism rs3753394 (P = .028) as well as an 8-allele CFH haplotype (P = .029) after correction for age, gender, and smoking. None of the other plasma markers was related to AMD status in our cohort.

CONCLUSIONS:

Our investigation of the gene-environment interaction involved in AMD revealed a relationship between a plasma biomarker of oxidative stress, CySS, and CFH genotype. These data suggest a potential association between inflammatory regulators and redox status in AMD pathogenesis.

PMID:
22035603
PMCID:
PMC3288635
DOI:
10.1016/j.ajo.2011.08.033
[Indexed for MEDLINE]
Free PMC Article
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