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Dialogues Clin Neurosci. 2002 Dec;4(4):402-7.

Challenges in the development of clinical trials for major depressive disorder: lessons learned from trials in minor depression.

Author information

1
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, Calif, USA; Department of Psychiatry, University of California, Los Angeles, Los Angeles, Calif, USA.

Abstract

This paper reviews some of the challenges faced by individuals who design and implement clinical trials of potential antidepressant medications. Particular emphasis is placed on questioning the validity of some of the theoretical assumptions that form the underpinnings of most conventional trials. Work from our group developing clinical trial methodology for minor depression is used as an example of how alternate constructs may be helpful to differentiate drug-placebo differences.

KEYWORDS:

antidepressant; clinical methodology; clinical trial design; depression; major depressive disorder; minor depression

PMID:
22034443
PMCID:
PMC3181702
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