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Dialogues Clin Neurosci. 2002 Dec;4(4):325-8.

Drug discovery and mental illness.

Author information

1
National Institute of Mental Health, Bethescla, Mel, USA.

Abstract

Mental disorders are among the most disabling of all diseases. Effective well-documented medications have been available for many decades. Yet, limited understanding of the pathophysiology of mental disorders has impeded the development of novel treatments. Drug discovery must move toward a net* mechanism-based paradigm using the tools of contemporary genetic and molecular medicine. At the same time, this new paradigm must be matched by an equivalent effort to modernize established approaches to clinical trials methodology.

KEYWORDS:

clinical trial; drug development; mechanism-based paradigm; mental Illness

PMID:
22033799
PMCID:
PMC3181695
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