Format

Send to

Choose Destination
Pediatr Nephrol. 2012 Oct;27(10):1847-54. doi: 10.1007/s00467-011-2029-0. Epub 2011 Oct 28.

Acute kidney injury: a conspiracy of Toll-like receptor 4 on endothelia, leukocytes, and tubules.

Author information

1
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA. Christopher.lu@utsouthwestern.edu

Abstract

Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia-reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored.

PMID:
22033798
PMCID:
PMC3523189
DOI:
10.1007/s00467-011-2029-0
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center