Format

Send to

Choose Destination
Immunogenetics. 2012 Apr;64(4):261-5. doi: 10.1007/s00251-011-0584-y. Epub 2011 Oct 29.

Association of CISH -292A/T genetic variant with hepatitis B virus infection.

Author information

1
Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse, 27, 72074, Tübingen, Germany.

Abstract

Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1-1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23-2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population.

PMID:
22033525
DOI:
10.1007/s00251-011-0584-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center