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Matrix Biol. 2012 Jan;31(1):3-16. doi: 10.1016/j.matbio.2011.10.001. Epub 2011 Oct 18.

Molecular functions of syndecan-1 in disease.

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1
Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.

Abstract

Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling. The significance of syndecan-1 interactions in disease is underscored by the striking pathological phenotypes seen in the syndecan-1 null mice when they are challenged with disease-instigating agents or conditions. This review discusses the key molecular functions of syndecan-1 in modulating the onset, progression, and resolution of inflammatory diseases, cancer, and infection.

PMID:
22033227
PMCID:
PMC3568394
DOI:
10.1016/j.matbio.2011.10.001
[Indexed for MEDLINE]
Free PMC Article
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