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Microbes Infect. 2012 Mar;14(3):207-16. doi: 10.1016/j.micinf.2011.10.001. Epub 2011 Oct 20.

Iron metabolism and the innate immune response to infection.

Author information

1
John Carroll University, Department of Biology, 20700 North Park Boulevard, University Heights, OH 44118, USA.

Abstract

Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.

PMID:
22033148
PMCID:
PMC3270215
DOI:
10.1016/j.micinf.2011.10.001
[Indexed for MEDLINE]
Free PMC Article

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