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J Chromatogr A. 2011 Dec 9;1218(49):8813-25. doi: 10.1016/j.chroma.2011.10.009. Epub 2011 Oct 10.

Mixed-mode chromatography and its applications to biopolymers.

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Institute of Modern Separation Science, Northwest University, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Xi'an 710069, China.


Mixed-mode chromatography is a type of chromatography in which a chromatographic stationary phase interacts with solutes through more than one interaction mode. This technique has been growing rapidly because of its advantages over conventional chromatography, such as its high resolution, high selectivity, high sample loading, high speed, and the ability to replace two conventionally corresponding columns in certain circumstances. In this work, some aspects of the development of mixed-mode chromatography are reviewed, such as stationary phase preparation, combinations of various separation modes, separation mechanisms, typical applications to biopolymers and peptides, and future prospects.

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